Why Do Magic Mushrooms Cause Nausea?
- Dustin C
- Nov 30, 2024
- 2 min read
Updated: Dec 2, 2024

Magic mushrooms have been gaining attention for their ability to open doors to self-discovery, enhance creativity, and even aid in therapeutic healing. However, despite their benefits, many users report experiencing nausea as a side effect. This uncomfortable sensation can detract from what might otherwise be a profound and meaningful journey. Why does this happen, and how can you reduce or avoid it? Let’s dive in.
Serotonin’s Role in Digestion
While serotonin is widely recognized for its role in mood regulation, it’s lesser-known that approximately 90% of the body's serotonin resides in the gut. This neurotransmitter helps control essential digestive functions, including motility and intestinal muscle contractions.
When you consume magic mushrooms, the psilocybin within them interacts with serotonin receptors in both your brain and gastrointestinal tract. This disruption in serotonin signaling can cause your digestive system to act out of sync, leading to nausea.
The Body’s Stress Response
Magic mushrooms don’t just affect your gut—they also impact your entire body as it processes the compound’s effects. As psilocybin starts to alter your perception, it may trigger mild stress or unease as your system adjusts. This heightened state can manifest physically, with nausea being a common symptom of your body's attempt to recalibrate during this altered state.
The Digestive Challenge of Mushrooms
On a more physical level, raw or dried mushrooms themselves can be tough to digest. The fibrous cell walls of mushrooms contain a substance called chitin, which many humans struggle to break down. This can irritate the stomach lining and exacerbate feelings of queasiness.
Tips to Reduce or Avoid Nausea
Fortunately, there are several strategies to minimize nausea when consuming magic mushrooms:
Prepare Your Mushrooms
Tea Preparation: Brewing mushrooms into tea is a popular way to ease digestion. Straining the mushroom material before drinking can reduce the chitin content and lighten the load on your stomach.
Lemon Tekking: Soaking mushrooms in lemon juice before consumption can help pre-digest the compounds, potentially making the experience smoother.
Support Your Stomach
Ginger: Known for its anti-nausea properties, ginger is a natural ally. Sip ginger tea, chew on candied ginger, or take ginger supplements before your trip.
Small Snacks: Eating a light, bland snack like toast or crackers beforehand can buffer your stomach without overloading it. Avoid rich, heavy, or spicy foods before your session.
Start Low, Go Slow
Especially for beginners, starting with a low dose of magic mushrooms can help your body adjust to the experience gradually, reducing the risk of nausea.
Stay Relaxed
Stress and anxiety can amplify physical discomfort. Practice mindfulness or engage in calming activities, like deep breathing or meditation, before and during your trip.
Final Thoughts
While nausea can be an inconvenient part of consuming magic mushrooms, it is usually temporary and manageable. Preparing carefully, staying calm, and supporting your digestion can minimize discomfort, allowing you to focus on the transformative potential of your experience. With a little planning, you can make your journey smoother and more rewarding.